Holy Cross College
Bioinfomatics Infrastructure Facility (BIF)

Sponsored by DBT.BTIS, Ministry of Science & Technology, Govt. of INDIA


Department of Biotechnology and Bioinformatics

Research Areas

  • Sequence and Structure Analysis
  • Signaling pathway analysis and data mining
  • Molecular Modeling
  • Identification of Potential Drug Targets


Patent No.:244666; Journal No. 51/2010

Title of the invention : A process for preparation of a novel compound, 5,6-dihydroxy-3-[(4-hydroxy-6(hydroxymethyl)-3,5-DI[3,4,5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-2pyranyl] oxytetrahydro-2H-2-pyranyl)oxy] -2-methoxy-10, 13- imethylperhydrocyclopenta [α] phenanthren-17-yl (phenyl)methylacetate from Syzygium cumini  skeels, seeds with antibacterial and antidiabetic activity.

Patent No.:246537 -2011

Title of the invention : A process for preparation of a novel compound Gymnemic triacetate from Gymnema sylvestre R. BR.leaves with antidiabetic activity

Ongoing Projects

Software development

Identification of a particular target and pharmacokinetic property for a ligand is a tedious process involving high cost and time. Cancer is a complex disease comprising of a number of signaling molecules in action, making the exploration of targeted drug action, a complex process. Hence, the DBT-BIF Centre of Holy Cross College is working on developing software that is built up with pharmacokinetic informations of various cancer markers and several generalized signaling pathways involved. This stands as a key area of research ongoing in the centre that would support in predicting the targeted activity of a drug in a short period of time.

Phytodrugs for Cancer

Cancer is the most dreadful diseases causes by the abnormal growth of cells in the body. In many countries cancer is the second leading cause of death after heart diseases. Because of the high death rate associated with cancer and because of serious side effects of chemotherapy and radiation therapy, many cancers patients seek alternative or complementary methods of treatment. This in turn justifies the interest in search of possible anticancer agents from the plants. In the light of this, the BIF centre of Holy Cross College is searching for lead molecules in plants through in silicoin vitro and in vivo approaches. Research scholars of the department are on their way to achieve this objective.

Screening of DNA binding blockers against Staphylococcus aureus

Antibiotic resistance is one of the most serious health threats threatening all over the world. Staphylococcus aureus is the most common bacteria showing resistance to various antibiotics In concurrent to these, discovery of novel drug for antibiotic resistance attains more interest. The centre has involved in searching inhibitors targeting DNA of Staphylococcus aureus. The centre has already screened several chemical compounds by using various bioinformatic analysis like pharamacophore mapping, Qm/MM docking etc.

Medicinal herbs for Diabetes

Diabetes mellitus (DM) is a non-communicable disease, which is considered one of the five leading causes of death in the world. About 150 million people suffer from diabetes worldwide, which is almost five times more than the estimates ten years ago and this may be doubled by the year 2030. Diabetes mellitus results when there is an inadequate functional mass of pancreatic β cells.Islets of Langerhans, irregularly shaped patches of endocrine tissue located within the pancreas of most vertebrates. The most common islet cell, beta cell, produces insulin, the major hormone in the regulation of carbohydrates, fat, and protein metabolism. In type 1 diabetes, immune-mediated destruction of β cells leaves a markedly reduced β cell mass. Currently, the centre focuses on the various approaches to identify the mode of beta cell regeneration aided by the phytocompounds through in silico and in vivo approaches.


Database for Identification of Cancer Effects

The database is the collection of cancer drugs with their physiochemical and structural properties, their cancer targets and side-effects